Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology

Lasse Pihlstrøm; Gemma Shireby; Hanneke Geut; Sandra Pilar Henriksen; Annemieke J. M. Rozemuller; Jon-Anders Tunold; Eilis Hannon; Paul Francis; Alan J. Thomas; Seth Love; Jonathan Mill; Wilma D. J. van de Berg; Mathias Toft

doi:10.1038/s41467-022-32619-z

Nature Communications (Aug 2022)

Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology

Lasse Pihlstrøm,
Gemma Shireby,
Hanneke Geut,
Sandra Pilar Henriksen,
Annemieke J. M. Rozemuller,
Jon-Anders Tunold,
Eilis Hannon,
Paul Francis,
Alan J. Thomas,
Seth Love,
Jonathan Mill,
Wilma D. J. van de Berg,
Mathias Toft

Affiliations

Lasse Pihlstrøm: Department of Neurology, Oslo University Hospital
Gemma Shireby: University of Exeter Medical School, College of Medicine and Health, University of Exeter
Hanneke Geut: Amsterdam UMC, Vrije Universiteit, Department of Anatomy and Neurosciences, Amsterdam Neuroscience
Sandra Pilar Henriksen: Department of Neurology, Oslo University Hospital
Annemieke J. M. Rozemuller: Amsterdam UMC, Vrije Universiteit, Department of Pathology, Amsterdam Neuroscience
Jon-Anders Tunold: Department of Neurology, Oslo University Hospital
Eilis Hannon: University of Exeter Medical School, College of Medicine and Health, University of Exeter
Paul Francis: University of Exeter Medical School, College of Medicine and Health, University of Exeter
Alan J. Thomas: Translational and Clinical Research Institute, Newcastle University
Seth Love: Dementia Research Group, Bristol Medical School, University of Bristol
Jonathan Mill: University of Exeter Medical School, College of Medicine and Health, University of Exeter
Wilma D. J. van de Berg: Amsterdam UMC, Vrije Universiteit, Department of Anatomy and Neurosciences, Amsterdam Neuroscience
Mathias Toft: Department of Neurology, Oslo University Hospital

DOI: https://doi.org/10.1038/s41467-022-32619-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Parkinson’s disease and dementia with Lewy bodies are closely related neurodegenerative disorders, although the epigenetic similarities are not well known. Here, the authors study Lewy pathology and DNA methylation in postmortem human frontal cortex, identifying differentially methylated genomic loci.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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