Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Adekunle Alabi; Xiao-Dan Xia; Hong-Mei Gu; Faqi Wang; Shi-Jun Deng; Nana Yang; Ayinuer Adijiang; Donna N. Douglas; Norman M. Kneteman; Yazhuo Xue; Li Chen; Shucun Qin; Guiqing Wang; Da-Wei Zhang

doi:10.1038/s41467-021-22167-3

Nature Communications (Mar 2021)

Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Adekunle Alabi,
Xiao-Dan Xia,
Hong-Mei Gu,
Faqi Wang,
Shi-Jun Deng,
Nana Yang,
Ayinuer Adijiang,
Donna N. Douglas,
Norman M. Kneteman,
Yazhuo Xue,
Li Chen,
Shucun Qin,
Guiqing Wang,
Da-Wei Zhang

Affiliations

Adekunle Alabi: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta
Xiao-Dan Xia: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta
Hong-Mei Gu: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta
Faqi Wang: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta
Shi-Jun Deng: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta
Nana Yang: Experimental Center for Medical Research, Weifang Medical University
Ayinuer Adijiang: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta
Donna N. Douglas: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta
Norman M. Kneteman: Department of Surgery, Faculty of Medicine and Dentistry, University of Alberta
Yazhuo Xue: Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences)
Li Chen: Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences)
Shucun Qin: Institute of Atherosclerosis in Shandong First Medical University (Shandong Academy of Medical Sciences)
Guiqing Wang: Department of Orthopedics, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital
Da-Wei Zhang: The Department of Pediatrics and Group on the Molecular and Cell Biology of Lipids, Faculty of Medicine and Dentistry, University of Alberta

DOI: https://doi.org/10.1038/s41467-021-22167-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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