Human leukocyte antigen susceptibility genes in multiple sclerosis

Abstract

Multiple sclerosis (MS) is an immune ⁃ related demyelinating disease of the central nervous system. The onset age of MS is usually between 20-40 years, showing a heterogeneous clinical feature. Due to the high disability rate, MS causes a huge burden to the society. MS is a complex disease caused by the genetic and environmental factors, in which genetic factors play a critical role. HLA gene complex is the most important determinant in MS risk, with a risk factor rate more than 60%. HLA gene complex has been a focus in MS research worldwide. DOI：10.3969/j.issn.1672⁃6731.2012.02.006

Keywords

• Multiple sclerosis
• HLA antigens
• Genetics
• Review