iScience (Aug 2022)
Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research
- Bogdan Mateescu,
- Jennifer C. Jones,
- Roger P. Alexander,
- Eric Alsop,
- Ji Yeong An,
- Mohammad Asghari,
- Alex Boomgarden,
- Laura Bouchareychas,
- Alfonso Cayota,
- Hsueh-Chia Chang,
- Al Charest,
- Daniel T. Chiu,
- Robert J. Coffey,
- Saumya Das,
- Peter De Hoff,
- Andrew deMello,
- Crislyn D’Souza-Schorey,
- David Elashoff,
- Kiarash R. Eliato,
- Jeffrey L. Franklin,
- David J. Galas,
- Mark B. Gerstein,
- Ionita H. Ghiran,
- David B. Go,
- Stephen Gould,
- Tristan R. Grogan,
- James N. Higginbotham,
- Florian Hladik,
- Tony Jun Huang,
- Xiaoye Huo,
- Elizabeth Hutchins,
- Dennis K. Jeppesen,
- Tijana Jovanovic-Talisman,
- Betty Y.S. Kim,
- Sung Kim,
- Kyoung-Mee Kim,
- Yong Kim,
- Robert R. Kitchen,
- Vaughan Knouse,
- Emily L. LaPlante,
- Carlito B. Lebrilla,
- L. James Lee,
- Kathleen M. Lennon,
- Guoping Li,
- Feng Li,
- Tieyi Li,
- Tao Liu,
- Zirui Liu,
- Adam L. Maddox,
- Kyle McCarthy,
- Bessie Meechoovet,
- Nalin Maniya,
- Yingchao Meng,
- Aleksandar Milosavljevic,
- Byoung-Hoon Min,
- Amber Morey,
- Martin Ng,
- John Nolan,
- Getulio P. De Oliveira Junior,
- Michael E. Paulaitis,
- Tuan Anh Phu,
- Robert L. Raffai,
- Eduardo Reátegui,
- Matthew E. Roth,
- David A. Routenberg,
- Joel Rozowsky,
- Joseph Rufo,
- Satyajyoti Senapati,
- Sigal Shachar,
- Himani Sharma,
- Anil K. Sood,
- Stavros Stavrakis,
- Alessandra Stürchler,
- Muneesh Tewari,
- Juan P. Tosar,
- Alexander K. Tucker-Schwartz,
- Andrey Turchinovich,
- Nedyalka Valkov,
- Kendall Van Keuren-Jensen,
- Kasey C. Vickers,
- Lucia Vojtech,
- Wyatt N. Vreeland,
- Ceming Wang,
- Kai Wang,
- ZeYu Wang,
- Joshua A. Welsh,
- Kenneth W. Witwer,
- David T.W. Wong,
- Jianping Xia,
- Ya-Hong Xie,
- Kaichun Yang,
- Mikołaj P. Zaborowski,
- Chenguang Zhang,
- Qin Zhang,
- Angela M. Zivkovic,
- Louise C. Laurent
Affiliations
- Bogdan Mateescu
- Brain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland; Corresponding author
- Jennifer C. Jones
- Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA; Corresponding author
- Roger P. Alexander
- Extracellular RNA Communication Consortium, Phoenix, AZ 85254, USA
- Eric Alsop
- Neurogenomics Division, TGen, Phoenix, AZ 85004, USA
- Ji Yeong An
- Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
- Mohammad Asghari
- Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland
- Alex Boomgarden
- Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
- Laura Bouchareychas
- Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA
- Alfonso Cayota
- Functional Genomics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay; University Hospital, Universidad de la República, Montevideo 11600, Uruguay
- Hsueh-Chia Chang
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Al Charest
- Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
- Daniel T. Chiu
- Department of Chemistry and Bioengineering, University of Washington, Seattle, WA 98195, USA
- Robert J. Coffey
- Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA
- Saumya Das
- Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
- Peter De Hoff
- Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA
- Andrew deMello
- Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland
- Crislyn D’Souza-Schorey
- Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
- David Elashoff
- Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
- Kiarash R. Eliato
- Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
- Jeffrey L. Franklin
- Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37235, USA
- David J. Galas
- Pacific Northwest Research Institute, Seattle, WA 98122, USA
- Mark B. Gerstein
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06520, USA
- Ionita H. Ghiran
- Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
- David B. Go
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Stephen Gould
- Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
- Tristan R. Grogan
- Department of Medicine Statistics Core, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA
- James N. Higginbotham
- Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
- Florian Hladik
- Departments of Obstetrics and Gynecology, and Medicine, University of Washington, Seattle, WA, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
- Tony Jun Huang
- Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA
- Xiaoye Huo
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Elizabeth Hutchins
- Neurogenomics Division, TGen, Phoenix, AZ 85004, USA
- Dennis K. Jeppesen
- Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
- Tijana Jovanovic-Talisman
- Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
- Betty Y.S. Kim
- Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
- Sung Kim
- Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
- Kyoung-Mee Kim
- Department of Pathology & Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
- Yong Kim
- Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA
- Robert R. Kitchen
- Corrigan Minehan Heart Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
- Vaughan Knouse
- Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
- Emily L. LaPlante
- Bioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
- Carlito B. Lebrilla
- Department of Chemistry, University of California, Davis, CA 95616, USA
- L. James Lee
- Department of Chemical and Biomolecular Engineering and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
- Kathleen M. Lennon
- Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
- Guoping Li
- Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
- Feng Li
- Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA
- Tieyi Li
- Department of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA
- Tao Liu
- Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA
- Zirui Liu
- Department of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA
- Adam L. Maddox
- Department of Molecular Medicine, Beckman Research Institute of the City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA
- Kyle McCarthy
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Bessie Meechoovet
- Neurogenomics Division, TGen, Phoenix, AZ 85004, USA
- Nalin Maniya
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Yingchao Meng
- Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland
- Aleksandar Milosavljevic
- Bioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences Baylor College of Medicine, Houston, TX 77030, USA
- Byoung-Hoon Min
- Department of Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, South Korea
- Amber Morey
- Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA
- Martin Ng
- Northern California Institute for Research and Education, San Francisco, CA 94121, USA
- John Nolan
- Scintillon Institute, San Diego, CA, USA
- Getulio P. De Oliveira Junior
- Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
- Michael E. Paulaitis
- Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
- Tuan Anh Phu
- Northern California Institute for Research and Education, San Francisco, CA 94121, USA
- Robert L. Raffai
- Department of Surgery, Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Northern California Institute for Research and Education, San Francisco, CA 94121, USA; Department of Veterans Affairs, Surgical Service (112G), San Francisco VA Medical Center, San Francisco, CA 94121, USA
- Eduardo Reátegui
- Department of Chemical and Biomolecular Engineering and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
- Matthew E. Roth
- Bioinformatics Research Laboratory, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
- David A. Routenberg
- Meso Scale Diagnostics, LLC, Rockville, MD 20850, USA
- Joel Rozowsky
- Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
- Joseph Rufo
- Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA
- Satyajyoti Senapati
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Sigal Shachar
- Meso Scale Diagnostics, LLC, Rockville, MD 20850, USA
- Himani Sharma
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Anil K. Sood
- Department of Gynecologic Oncology & Reproductive Medicine, University of Texas MD Aderson Cancer Center, Houston, TX 77030, USA
- Stavros Stavrakis
- Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland
- Alessandra Stürchler
- Brain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland; Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland
- Muneesh Tewari
- Department of Internal Medicine, Hematology/Oncology Division, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Rogel Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
- Juan P. Tosar
- Functional Genomics Unit, Institut Pasteur de Montevideo, Montevideo 11400, Uruguay; Analytical Biochemistry Unit, School of Science, Universidad de la República, Montevideo 11400, Uruguay
- Alexander K. Tucker-Schwartz
- Meso Scale Diagnostics, LLC, Rockville, MD 20850, USA
- Andrey Turchinovich
- Cancer Genome Research (B063), German Cancer Research Center DKFZ, Heidelberg 69120, Germany; Heidelberg Biolabs GmbH, Heidelberg 69120, Germany
- Nedyalka Valkov
- Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
- Kendall Van Keuren-Jensen
- Neurogenomics Division, TGen, Phoenix, AZ 85004, USA
- Kasey C. Vickers
- Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
- Lucia Vojtech
- Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195, USA
- Wyatt N. Vreeland
- Bioprocess Measurement Group, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
- Ceming Wang
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Kai Wang
- Institute for Systems Biology, Seattle, WA 98109, USA
- ZeYu Wang
- Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA
- Joshua A. Welsh
- Laboratory of Pathology Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
- Kenneth W. Witwer
- Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
- David T.W. Wong
- Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA
- Jianping Xia
- Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA
- Ya-Hong Xie
- Department of Materials Science & Engineering, University of California Los Angeles, Los Angeles, CA 90095-1595, USA
- Kaichun Yang
- Department of Mechanical Engineering and Material Science, Duke University, Durham, NC 27708, USA
- Mikołaj P. Zaborowski
- Department of Gynecology, Obstetrics and Gynecologic Oncology, Division of Gynecologic Oncology, Poznan University of Medical Sciences, 60-535 Poznań, Poland
- Chenguang Zhang
- Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA
- Qin Zhang
- Department of Medicine/Gastroenterology and Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
- Angela M. Zivkovic
- Department of Nutrition, University of California, Davis, CA 95616, USA
- Louise C. Laurent
- Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, La Jolla, San Diego, CA 92093, USA; Corresponding author
- Journal volume & issue
-
Vol. 25,
no. 8
p. 104653
Abstract
Summary: The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the program (ERCC2, 2019–2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2’s current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.
