Nature Communications (May 2017)
Histone variant H2A.J accumulates in senescent cells and promotes inflammatory gene expression
- Kévin Contrepois,
- Clément Coudereau,
- Bérénice A. Benayoun,
- Nadine Schuler,
- Pierre-François Roux,
- Oliver Bischof,
- Régis Courbeyrette,
- Cyril Carvalho,
- Jean-Yves Thuret,
- Zhihai Ma,
- Céline Derbois,
- Marie-Claire Nevers,
- Hervé Volland,
- Christophe E. Redon,
- William M. Bonner,
- Jean-François Deleuze,
- Clotilde Wiel,
- David Bernard,
- Michael P. Snyder,
- Claudia E. Rübe,
- Robert Olaso,
- François Fenaille,
- Carl Mann
Affiliations
- Kévin Contrepois
- Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
- Clément Coudereau
- Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
- Bérénice A. Benayoun
- Department of Genetics, Stanford University
- Nadine Schuler
- Department of Radiation Oncology, Saarland University
- Pierre-François Roux
- Department of Cell Biology and Infection, Institut Pasteur/INSERM U933, Laboratory of Nuclear Organization and Oncogenesis
- Oliver Bischof
- Department of Cell Biology and Infection, Institut Pasteur/INSERM U933, Laboratory of Nuclear Organization and Oncogenesis
- Régis Courbeyrette
- Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
- Cyril Carvalho
- Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
- Jean-Yves Thuret
- Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
- Zhihai Ma
- Department of Genetics, Stanford University
- Céline Derbois
- CEA, CNG
- Marie-Claire Nevers
- CEA, Service de Pharmacologie et Immunoanalyse (SPI), INRA, Université Paris-Saclay
- Hervé Volland
- CEA, Service de Pharmacologie et Immunoanalyse (SPI), INRA, Université Paris-Saclay
- Christophe E. Redon
- Laboratory of Molecular Pharmacology, C.C.R., N.C.I., N.I.H.
- William M. Bonner
- Laboratory of Molecular Pharmacology, C.C.R., N.C.I., N.I.H.
- Jean-François Deleuze
- CEA, CNG
- Clotilde Wiel
- Inserm U1052, Centre de Recherche en Cancérologie de Lyon, CNRS UMR5286, Centre Léon Bérard, Université de Lyon
- David Bernard
- Inserm U1052, Centre de Recherche en Cancérologie de Lyon, CNRS UMR5286, Centre Léon Bérard, Université de Lyon
- Michael P. Snyder
- Department of Genetics, Stanford University
- Claudia E. Rübe
- Department of Radiation Oncology, Saarland University
- Robert Olaso
- CEA, CNG
- François Fenaille
- CEA, IBITECS, Service de Pharmacologie et d'Immunoanalyse, UMR 0496, Laboratoire d'Etude du Métabolisme des Médicaments, MetaboHUB-Paris, Université Paris Saclay
- Carl Mann
- Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
- DOI
- https://doi.org/10.1038/ncomms14995
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Senescence of mammalian cells is characterized by proliferative arrest and expression of an inflammatory phenotype. Here the authors show the H2A variant H2A.J, found only in mammals, accumulates following persistent DNA damage or natural aging.
