Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse

Yong Soo Park; Yeonji Kim; Sung Won Kim; In-Beom Kim

doi:10.1186/s42649-020-00031-w

Applied Microscopy (Jun 2020)

Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse

Yong Soo Park,
Yeonji Kim,
Sung Won Kim,
In-Beom Kim

Affiliations

Yong Soo Park: Department of Anatomy, College of Medicine, The Catholic University of Korea
Yeonji Kim: Department of Anatomy, College of Medicine, The Catholic University of Korea
Sung Won Kim: Department of Otolaryngology-Head and Neck Surgery, Seoul St Mary’s Hospital, College of Medicine, The Catholic University of Korea
In-Beom Kim: Department of Anatomy, College of Medicine, The Catholic University of Korea

DOI: https://doi.org/10.1186/s42649-020-00031-w
Journal volume & issue: Vol. 50, no. 1
pp. 1 – 3

Abstract

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Abstract The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differential interference contrast (DIC) filters. The images clearly demonstrated that DiI-labeled hTMSCs have rhodopsin-immunoreactive appendages, indicating differentiation of transplanted hTMSC into rod photoreceptor. Conclusively, the finding suggests therapeutic potential of hTMSCs in retinal degeneration.

Published in Applied Microscopy

ISSN: 2287-4445 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Science: Natural history (General): Microscopy
Website: https://appmicro.springeropen.com/

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