Metabolomics Deciphering Therapeutic Effects and Mechanism of Traditional Chinese Medicines

Wei-Wei Ma; Ai-Hua Zhang; Hui Sun; Xiang-Cai Meng; Xi-Jun Wang

doi:10.15806/j.issn.2311-8571.2016.0027

World Journal of Traditional Chinese Medicine (Nov 2016)

Metabolomics Deciphering Therapeutic Effects and Mechanism of Traditional Chinese Medicines

Wei-Wei Ma,
Ai-Hua Zhang,
Hui Sun,
Xiang-Cai Meng,
Xi-Jun Wang

Affiliations

Wei-Wei Ma: National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center, Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
Ai-Hua Zhang: National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center, Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
Hui Sun: National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center, Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
Xiang-Cai Meng: National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center, Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China
Xi-Jun Wang: National TCM Key Laboratory of Serum Pharmacochemistry, Sino-America Chinmedomics Technology Cooperation Center, Research Center of Chinmedomics (State Administration of TCM), Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China

DOI: https://doi.org/10.15806/j.issn.2311-8571.2016.0027
Journal volume & issue: Vol. 2, no. 3
pp. 17 – 24

Abstract

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Traditional Chinese medicine (TCM), an ancient medical system, has the advantages of multi-targeting and multi-ingredient preparations, and is different from modern pharmacology. However, because of the complexity of TCM and the limitation of present investigation method, the research for deciphering the scientific basis and systematic features of TCM is difficult to go further. Metabolomics has a significant increased study in recent years and enables mapping of early biochemical changes in disease and hence provides an opportunity to develop predictive biomarkers. Moreover, its method and design resemble those of traditional Chinese medicine. Therefore, it can provide useful tools for exploring essence of TCM, and will help to in-depth understand Chinese medicine syndromes. In this mini-paper, particular attention will be paid to the past successes in applications of robust metabolomics to contribute to small metabolites discovery in TCM development.

Published in World Journal of Traditional Chinese Medicine

ISSN: 2311-8571 (Print)
Publisher: Wolters Kluwer Medknow Publications
Country of publisher: India
LCC subjects: Medicine: Medicine (General)
Website: https://journals.lww.com/wtcm/Pages/default.aspx

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