FEATURES OF DIAGNOSIS OF AGE-OLD HYPOGONADISM IN MEN WITH CORONARY ARTERY DISEASE

Abstract

At present, the issue of providing care to patients with cardiovascular disease (CVD), in particular coronary heart disease (CHD), which, despite advances in modern medicine, remains the leading cause of death in Ukraine and around the world. According to the Global Burden of Disease study for 2019, cardiovascular disease is the most common cause of death in Ukraine, accounting for 64.3% of total deaths in 2019. Well-known conditions that affect the cardiovascular prognosis include smoking, hypertension, lipid metabolism disorders, genetic predisposition, male gender, age, diabetes, insufficient physical activity, but at the same time the search for new factors that modify it continues. These include hypogonadism in men, which affects the course of cardiovascular disease (CVD), coronary heart disease (CHD) and cardiovascular prognosis in men, shown in studies. In view of this, the question arises of developing algorithms for the diagnosis of androgen deficiency in men with coronary heart disease. This prospective study included 37 men with chronic coronary heart disease (stable angina pectoris, postinfarction and atherosclerotic cardiosclerosis), aged 45 to 65 years, who were hospitalized. In addition to routine clinical and paraclinical examinations, patients were tested for total and bound plasma testosterone, prostate specific antigen (PSA); There was also a survey on the AMS questionnaire (The Aging Males’ Symptoms Scale), a questionnaire for men on the presence of age symptoms, where the patient is asked to answer a series of questions, assessing the severity of age symptoms from 1 (no symptoms) to 5 (very severe) after which the sum of points is calculated). As a result of the study, it was found that its sensitivity to detect androgen deficiency was 100%, while the specificity – 67.7%, respectively. Spearman’s rank correlation coefficient between total testosterone levels and the score obtained from the AMS questionnaire was -0.63 (p<0.01), which corresponds to a moderate negative correlation. Thus, it can be concluded that testing on the AMS questionnaire can be used to screen for the presence of hypogonadism in men with coronary heart disease.

Keywords

• androgen deficiency
• hypogonadism
• coronary artery disease.