VITAMIN D STATUS IN WOMEN WITH POSTMENOPAUSAL OSTEOPOROSIS

Abstract

The perturbation status of vitamin D can be manifested as insufficiency, deficiency and excessiveness. Vitamin D status within the organism is determined by measuring the level of 25(OH)D in the serum.The aim of this paper was to determine the vitamin D status in postmenopausal women with newly diagnosed osteoporosis as well as to correlate vitamin D status with bone mineral density (BMD) and bones' fractures.The research included 58 postmenopausal women who have recently been given the diagnosis of postmenopausal osteoporosis. All the examinees were determined with the level of 25(OH)D as well as the levels of unspecific markers of the bone metabolism. All of the examinees were defined with their bone mineral density on the lumbar spine and hip, measured with DEXA densitometer.The average age of the examinees was 60,46±6,55 years, average duration of menopause 15,02±9,25 years and average concentration of 25(OH)D 46,45±14,68 nmol/L. Our results has shown the deficiency of vitamin D in 89,76% of the examinees with postmenopausal osteoporosis, positive correlation of the level of 25(OH)D and bone mineral density (BMD) and a significantly lower initial concentration of 25(OH)D with the examines with prior bone fractures opposed to those without fractures (37,57±13,08 vs. 51,22±17,26 nmol/L; p<0,02). The obtained results show that vitamine D deficiency in postmenopausal women with osteporosis present important risk factors for bones fractures as well as factors for decreasing the bone mineral density.

Keywords

• Vitamin D
• osteoporosis
• postmenopausal women