Communications Biology (Sep 2021)
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in the joints of rheumatoid arthritis patients
- Daniela Amaral-Silva,
- Rute Gonçalves,
- Rita C. Torrão,
- Rita Torres,
- Sandra Falcão,
- Maria João Gonçalves,
- Maria Paula Araújo,
- Maria José Martins,
- Carina Lopes,
- Agna Neto,
- José Marona,
- Tiago Costa,
- Walter Castelão,
- Ana Bento Silva,
- Inês Silva,
- Maria Helena Lourenço,
- Margarida Mateus,
- Nuno Pina Gonçalves,
- Santiago Manica,
- Manuela Costa,
- Fernando M. Pimentel-Santos,
- Ana Filipa Mourão,
- Jaime C. Branco,
- Helena Soares
Affiliations
- Daniela Amaral-Silva
- Human Immunobiology and Pathogenesis Group
- Rute Gonçalves
- Human Immunobiology and Pathogenesis Group
- Rita C. Torrão
- Human Immunobiology and Pathogenesis Group
- Rita Torres
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- Sandra Falcão
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- Maria João Gonçalves
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Maria Paula Araújo
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Maria José Martins
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Carina Lopes
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Agna Neto
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- José Marona
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Tiago Costa
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Walter Castelão
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Ana Bento Silva
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Inês Silva
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Maria Helena Lourenço
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Margarida Mateus
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Nuno Pina Gonçalves
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- Santiago Manica
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- Manuela Costa
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Fernando M. Pimentel-Santos
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- Ana Filipa Mourão
- iNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon
- Jaime C. Branco
- Hospital Egas Moniz, Rua da Junqueira n° 126
- Helena Soares
- Human Immunobiology and Pathogenesis Group
- DOI
- https://doi.org/10.1038/s42003-021-02659-0
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 16
Abstract
In order to identify how the synovial microenvironment impinges on CD4+ T cells pathogenic functions in Rheumatoid Arthritis (RA), Amaral-Silva examined RA patient blood and synovial fluif and identified the presence of a TLR4+ follicular helper T (Tfh) cell-like population. They provided mechanistic insight into how TLR4+ T cells uniquely reconcile an ability to promote systemic antibody production with a local synovial driven-tissue damage program.
