Nature Communications (Nov 2021)
RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination
- Qian Zhu,
- Jinzhou Huang,
- Hongyang Huang,
- Huan Li,
- Peiqiang Yi,
- Jake A. Kloeber,
- Jian Yuan,
- Yuping Chen,
- Min Deng,
- Kuntian Luo,
- Ming Gao,
- Guijie Guo,
- Xinyi Tu,
- Ping Yin,
- Yong Zhang,
- Jun Su,
- Jiayi Chen,
- Zhenkun Lou
Affiliations
- Qian Zhu
- Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Jinzhou Huang
- Department of Oncology, Mayo Clinic
- Hongyang Huang
- Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Huan Li
- Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Peiqiang Yi
- Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Jake A. Kloeber
- Department of Oncology, Mayo Clinic
- Jian Yuan
- Research Center for Translational Medicine, East Hospital, Tongji University School of medicine
- Yuping Chen
- Research Center for Translational Medicine, East Hospital, Tongji University School of medicine
- Min Deng
- Department of Oncology, Mayo Clinic
- Kuntian Luo
- Department of Oncology, Mayo Clinic
- Ming Gao
- Department of Oncology, Mayo Clinic
- Guijie Guo
- Department of Oncology, Mayo Clinic
- Xinyi Tu
- Department of Oncology, Mayo Clinic
- Ping Yin
- Department of Oncology, Mayo Clinic
- Yong Zhang
- Department of Oncology, Mayo Clinic
- Jun Su
- Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Jiayi Chen
- Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine
- Zhenkun Lou
- Department of Oncology, Mayo Clinic
- DOI
- https://doi.org/10.1038/s41467-021-27048-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
BRCA1 dysfunction sensitizes cancer cells to PARP inhibitors (PARPi) but the underlying mechanism is unclear. Here, the authors identify RNF19A as a determinant of PARPi sensitivity, showing that RNF19A ubiquitinates BARD1, negatively regulates the BRCA1-BARD1 complex, and inhibits homologous recombination.
