Nature Communications (Jan 2021)

Structural insights into TSC complex assembly and GAP activity on Rheb

  • Huirong Yang,
  • Zishuo Yu,
  • Xizi Chen,
  • Jiabei Li,
  • Ningning Li,
  • Jiaxuan Cheng,
  • Ning Gao,
  • Hai-Xin Yuan,
  • Dan Ye,
  • Kun-Liang Guan,
  • Yanhui Xu

DOI
https://doi.org/10.1038/s41467-020-20522-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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Tuberous sclerosis complex (TSC) regulates cell growth by controlling the activity of mTORC1. The structure of human TSC complex reveals an arch-shaped, asymmetric architecture and a 2:2:1 stoichiometry of TSC1, TSC2, and TBC1D7 subunits and suggests a mechanism by which TSC2 accelerates GTP hydrolysis against a small GTPase Rheb.