Nucleus (Jul 2012)
Radiopharmaceuticals in immunoscintigraphy and radioimmunotherapy
Abstract
The high morbidity-mortality of cancer makes this condition in Cuba, and at international level, a serious health problem. Radioimmunodiagnosis and radioimmunotherapy based in the growing biotechnological advances, and the actual knowledge of molecular and cellular biology, become a highly promising tools in the fight against cancer. In this work we present a brief review of the radiopharmaceuticals developed in our country starting from biomolecules produced en Cuba, as well as a panoramic of several monoclonal antibodies and radionuclides used in clinical applications. Radioimmunodiagnosis applications are based on murine monoclonal antibodies, produced in form of lyophilized kits for labeling. We also examined the perspectives of the application of radioimmunotherapy in Cuba starting from the international experiences, particularly in non-Hodgkin’s lymphoma treatment, keeping in mind the availability of different monoclonal antibodies already humanized, as well as of from the existing technologies in Cuban research-production centers.
