Nature Communications (Dec 2023)
Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
- Weiyin Zhou,
- Anja Fischer,
- Martin D. Ogwang,
- Wen Luo,
- Patrick Kerchan,
- Steven J. Reynolds,
- Constance N. Tenge,
- Pamela A. Were,
- Robert T. Kuremu,
- Walter N. Wekesa,
- Nestory Masalu,
- Esther Kawira,
- Tobias Kinyera,
- Isaac Otim,
- Ismail D. Legason,
- Hadijah Nabalende,
- Leona W. Ayers,
- Kishor Bhatia,
- James J. Goedert,
- Mateus H. Gouveia,
- Nathan Cole,
- Belynda Hicks,
- Kristine Jones,
- Michael Hummel,
- Mathias Schlesner,
- George Chagaluka,
- Nora Mutalima,
- Eric Borgstein,
- George N. Liomba,
- Steve Kamiza,
- Nyengo Mkandawire,
- Collins Mitambo,
- Elizabeth M. Molyneux,
- Robert Newton,
- Selina Glaser,
- Helene Kretzmer,
- Michelle Manning,
- Amy Hutchinson,
- Ann W. Hsing,
- Yao Tettey,
- Andrew A. Adjei,
- Stephen J. Chanock,
- Reiner Siebert,
- Meredith Yeager,
- Ludmila Prokunina-Olsson,
- Mitchell J. Machiela,
- Sam M. Mbulaiteye
Affiliations
- Weiyin Zhou
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Anja Fischer
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Martin D. Ogwang
- EMBLEM Study, St. Mary’s Hospital, Lacor
- Wen Luo
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Patrick Kerchan
- EMBLEM Study, Kuluva Hospital
- Steven J. Reynolds
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Constance N. Tenge
- EMBLEM Study, Moi University College of Health Sciences
- Pamela A. Were
- EMBLEM Study, Academic Model Providing Access To Healthcare (AMPATH)
- Robert T. Kuremu
- EMBLEM Study, Moi University College of Health Sciences
- Walter N. Wekesa
- EMBLEM Study, Moi University College of Health Sciences
- Nestory Masalu
- EMBLEM Study, Bugando Medical Center
- Esther Kawira
- EMBLEM Study, Shirati Health, Education, and Development Foundation
- Tobias Kinyera
- EMBLEM Study, St. Mary’s Hospital, Lacor
- Isaac Otim
- EMBLEM Study, St. Mary’s Hospital, Lacor
- Ismail D. Legason
- EMBLEM Study, Kuluva Hospital
- Hadijah Nabalende
- EMBLEM Study, St. Mary’s Hospital, Lacor
- Leona W. Ayers
- Department of Pathology, The Ohio State University
- Kishor Bhatia
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- James J. Goedert
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Mateus H. Gouveia
- Center for Research on Genomics & Global Health, NHGRI, National Institutes of Health
- Nathan Cole
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Belynda Hicks
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Kristine Jones
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Michael Hummel
- Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin
- Mathias Schlesner
- Biomedical Informatics, Data Mining and Data Analytics, University of Augsburg
- George Chagaluka
- Departments of Pediatrics and Surgery, College of Medicine, University of Malawi
- Nora Mutalima
- Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York
- Eric Borgstein
- Departments of Pediatrics and Surgery, College of Medicine, University of Malawi
- George N. Liomba
- Departments of Pediatrics and Surgery, College of Medicine, University of Malawi
- Steve Kamiza
- Departments of Pediatrics and Surgery, College of Medicine, University of Malawi
- Nyengo Mkandawire
- Departments of Pediatrics and Surgery, College of Medicine, University of Malawi
- Collins Mitambo
- Research Department, Ministry of Health
- Elizabeth M. Molyneux
- Departments of Pediatrics and Surgery, College of Medicine, University of Malawi
- Robert Newton
- Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York
- Selina Glaser
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Helene Kretzmer
- Department of Genome Regulation, Max Planck Institute for Molecular Genetics
- Michelle Manning
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Amy Hutchinson
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Ann W. Hsing
- Stanford Cancer Institute, Stanford University
- Yao Tettey
- Department of Pathology, University of Ghana Medical School, College of Health Sciences
- Andrew A. Adjei
- Department of Pathology, University of Ghana Medical School, College of Health Sciences
- Stephen J. Chanock
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Reiner Siebert
- Institute of Human Genetics, Ulm University and Ulm University Medical Center
- Meredith Yeager
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Ludmila Prokunina-Olsson
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Mitchell J. Machiela
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- Sam M. Mbulaiteye
- Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services
- DOI
- https://doi.org/10.1038/s41467-023-43881-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Abstract In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10−11 and 3.74×10−2, respectively). Autosomal mosaic chromosomal alterations are detected in 14.0% of Ghanaian men and increase with age. Mosaic chromosomal alterations in Burkitt lymphoma cases include gains on chromosomes 1q and 8, the latter spanning MYC, while mosaic chromosomal alterations in Burkitt lymphoma-free children include copy-neutral loss of heterozygosity on chromosomes 10, 14, and 16. Our results highlight mosaic chromosomal alterations in sub-Saharan African populations as a promising area of research.
