Advances in related research about hereditary connective tissue diseases and the occurrence and rupture of intracranial aneurysm

Abstract

The mechanism of occurrence and rupture of intracranial aneurysm is complex and may involve various environmental and genetic factors. Histopathological studies of intracranial aneurysm suggest a possible relationship between intracranial aneurysm and connective tissue diseases. Clinical studies have shown that patients suffering from hereditary connective tissue diseases are at significantly increased risk of multiple cerebrovascular diseases such as intracranial aneurysm. Further studies have found that mutations in associated gene loci involved in these hereditary diseases are closely related to the occurrence and development of intracranial aneurysm. Based on previous literatures, this study aims to review intracranial aneurysm related hereditary connective tissue diseases and important gene loci involved. doi：10.3969/j.issn.1672⁃6731.2021.02.009

Keywords

• intracranial aneurysm
• connective tissue diseases
• genetic diseases
• inborn
• genes
• mutation
• review