Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan

Abstract

Klebsiella pneumoniae shows increasing emergence of multidrug-resistant lineages, including strains resistant to all available antimicrobial drugs. We conducted whole-genome sequencing of 178 highly drug-resistant isolates from a tertiary hospital in Lahore, Pakistan. Phylogenetic analyses to place these isolates into global context demonstrate the expansion of multiple independent lineages, including K. quasipneumoniae.

Keywords

• Klebsiella
• ESBL
• extended-spectrum β-lactamase
• antimicrobial resistance
• neonatal infection
• multidrug resistance