Evaluation of the Correlation between the Alteration of Specific Biochemical Indicators levels in the Early Stages of Colorectal Cancer

Abstract

Background and Objective: Colorectal cancer is one of the most common cancers and considered to be leading causes of cancer death in the world. One of the problems with this type of cancer is its inability to be detected in early stage. The aim of present study was to evaluate the correlation between the serum levels of Fucosyltransferase-4 and galactin-3 in patients with early-stage of colorectal cancer. Methods: This case-control study was done on 40 patients with early stages of colorectal cancer and 40 healthy subjects. ELISA method was used to measure the serum levels of Fucosyltransferase-4 and galactin-3. To examine the correlation between the variables, correlation test and Pearson correlation coefficient index were used. Results: Fucosyltransferase-4 and galactin-3 levels were higher in patients with early-stage of colorectal cancer compared to healthy subjects. This difference was not significant. In patients with colorectal cancer, there was a significant relationship between the level of Fucosyltransferase-4 and galactin-3 (r=0.71, P=0.01). Conclusion: Simultaneous measurement of Fucosyltransferase-4 and galactin-3 is useful in identifying early-stage of colorectal cancer as a non-invasive laboratory method.

Keywords

• colorectal neoplasms
• fucosyltransferase-4
• galactin-3