Communications Biology (Dec 2022)
Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation
- Ly Pham,
- Padmini Komalavilas,
- Alex M. Eddie,
- Timothy E. Thayer,
- Dalton L. Greenwood,
- Ken H. Liu,
- Jaclyn Weinberg,
- Andrew Patterson,
- Joshua P. Fessel,
- Kelli L. Boyd,
- Jenny C. Schafer,
- Jamie L. Kuck,
- Aaron C. Shaver,
- David K. Flaherty,
- Brittany K. Matlock,
- Christiaan D. M. Wijers,
- C. Henrique Serezani,
- Dean P. Jones,
- Evan L. Brittain,
- Jeffrey C. Rathmell,
- Michael J. Noto
Affiliations
- Ly Pham
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Padmini Komalavilas
- Department of Medicine, Vanderbilt University Medical Center
- Alex M. Eddie
- Department of Medicine, Vanderbilt University Medical Center
- Timothy E. Thayer
- Department of Medicine, Vanderbilt University Medical Center
- Dalton L. Greenwood
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Ken H. Liu
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University
- Jaclyn Weinberg
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University
- Andrew Patterson
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Joshua P. Fessel
- Division of Clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health
- Kelli L. Boyd
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Jenny C. Schafer
- Department of Cell and Developmental Biology, Vanderbilt University
- Jamie L. Kuck
- Department of Medicine, Vanderbilt University Medical Center
- Aaron C. Shaver
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- David K. Flaherty
- Flow Cytometry Shared Resource, Vanderbilt University Medical Center
- Brittany K. Matlock
- Flow Cytometry Shared Resource, Vanderbilt University Medical Center
- Christiaan D. M. Wijers
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- C. Henrique Serezani
- Department of Medicine, Vanderbilt University Medical Center
- Dean P. Jones
- Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University
- Evan L. Brittain
- Department of Medicine, Vanderbilt University Medical Center
- Jeffrey C. Rathmell
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Michael J. Noto
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/s42003-022-04339-z
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
