International Journal of Nanomedicine (Jun 2020)

Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review

  • Rabiee N,
  • Ahmadi S,
  • Arab Z,
  • Bagherzadeh M,
  • Safarkhani M,
  • Nasseri B,
  • Rabiee M,
  • Tahriri M,
  • Webster TJ,
  • Tayebi L

Journal volume & issue
Vol. Volume 15
pp. 4237 – 4256

Abstract

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Navid Rabiee,1 Sepideh Ahmadi,2,3 Zeynab Arab,1 Mojtaba Bagherzadeh,1 Moein Safarkhani,1 Behzad Nasseri,4,5 Mohammad Rabiee,6 Mohammadreza Tahriri,7 Thomas J Webster,8 Lobat Tayebi7 1Department of Chemistry, Sharif University of Technology, Tehran, Iran; 2Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Chemical Engineering Department and Bioengineering Division, Hacettepe University, Beytepe, Ankara 06800, Turkey; 5Chemical Engineering and Applied Chemistry Department, Atilim University, Ankara, Turkey; 6Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; 7Marquette University School of Dentistry, Milwaukee, WI 53233, USA; 8Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USACorrespondence: Thomas J Webster; Mohammadreza Tahriri Email [email protected]; [email protected]: With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.Keywords: aptamer, polyethyleneimine, hybrid nanocomplexes, antibiotic, targeting, gene delivery systems

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