Frontiers in Cardiovascular Medicine (Mar 2023)
Screening approaches to cardiac amyloidosis in different clinical settings: Current practice and future perspectives
- Angelo Giuseppe Caponetti,
- Angelo Giuseppe Caponetti,
- Antonella Accietto,
- Antonella Accietto,
- Giulia Saturi,
- Giulia Saturi,
- Alberto Ponziani,
- Alberto Ponziani,
- Maurizio Sguazzotti,
- Maurizio Sguazzotti,
- Paolo Massa,
- Paolo Massa,
- Alessandro Giovannetti,
- Alessandro Giovannetti,
- Raffaello Ditaranto,
- Raffaello Ditaranto,
- Vanda Parisi,
- Vanda Parisi,
- Ornella Leone,
- Pietro Guaraldi,
- Pietro Cortelli,
- Pietro Cortelli,
- Christian Gagliardi,
- Christian Gagliardi,
- Simone Longhi,
- Simone Longhi,
- Nazzareno Galiè,
- Nazzareno Galiè,
- Elena Biagini,
- Elena Biagini
Affiliations
- Angelo Giuseppe Caponetti
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Angelo Giuseppe Caponetti
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Antonella Accietto
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Antonella Accietto
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Giulia Saturi
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Giulia Saturi
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Alberto Ponziani
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Alberto Ponziani
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Maurizio Sguazzotti
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Maurizio Sguazzotti
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Paolo Massa
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Paolo Massa
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Alessandro Giovannetti
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Alessandro Giovannetti
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Raffaello Ditaranto
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Raffaello Ditaranto
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Vanda Parisi
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Vanda Parisi
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Ornella Leone
- Department of Pathology, Cardiovascular and Cardiac Transplant Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Pietro Guaraldi
- IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy
- Pietro Cortelli
- IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy
- Pietro Cortelli
- Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Alma Mater Studiorum-University of Bologna, Bologna, Italy
- Christian Gagliardi
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Christian Gagliardi
- European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart, Bologna, Italy
- Simone Longhi
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Simone Longhi
- European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart, Bologna, Italy
- Nazzareno Galiè
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Nazzareno Galiè
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
- Elena Biagini
- Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
- Elena Biagini
- European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart, Bologna, Italy
- DOI
- https://doi.org/10.3389/fcvm.2023.1146725
- Journal volume & issue
-
Vol. 10
Abstract
Cardiac amyloidosis is a serious and progressive infiltrative disease caused by the deposition of amyloid fibrils in the heart. In the last years, a significant increase in the diagnosis rate has been observed owing to a greater awareness of its broad clinical presentation. Cardiac amyloidosis is frequently associated to specific clinical and instrumental features, so called “red flags”, and it appears to occur more commonly in particular clinical settings such as multidistrict orthopedic conditions, aortic valve stenosis, heart failure with preserved or mildly reduced ejection fraction, arrhythmias, plasma cell disorders. Multimodality approach and new developed techniques such PET fluorine tracers or artificial intelligence may contribute to strike up extensive screening programs for an early recognition of the disease.
Keywords
