Nature Communications (Jun 2020)
Type I interferon sensing unlocks dormant adipocyte inflammatory potential
- Calvin C. Chan,
- Michelle S. M. A. Damen,
- Maria E. Moreno-Fernandez,
- Traci E. Stankiewicz,
- Monica Cappelletti,
- Pablo C. Alarcon,
- Jarren R. Oates,
- Jessica R. Doll,
- Rajib Mukherjee,
- Xiaoting Chen,
- Rebekah Karns,
- Matthew T. Weirauch,
- Michael A. Helmrath,
- Thomas H. Inge,
- Senad Divanovic
Affiliations
- Calvin C. Chan
- Medical Scientist Training Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine
- Michelle S. M. A. Damen
- Department of Pediatrics, University of Cincinnati College of Medicine
- Maria E. Moreno-Fernandez
- Department of Pediatrics, University of Cincinnati College of Medicine
- Traci E. Stankiewicz
- Department of Pediatrics, University of Cincinnati College of Medicine
- Monica Cappelletti
- Department of Pediatrics, University of Cincinnati College of Medicine
- Pablo C. Alarcon
- Medical Scientist Training Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine
- Jarren R. Oates
- Immunology Graduate Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine
- Jessica R. Doll
- Department of Pediatrics, University of Cincinnati College of Medicine
- Rajib Mukherjee
- Department of Pediatrics, University of Cincinnati College of Medicine
- Xiaoting Chen
- The Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Rebekah Karns
- Department of Pediatrics, University of Cincinnati College of Medicine
- Matthew T. Weirauch
- Department of Pediatrics, University of Cincinnati College of Medicine
- Michael A. Helmrath
- Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center
- Thomas H. Inge
- Department of Surgery, Children’s Hospital Colorado
- Senad Divanovic
- Medical Scientist Training Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-16571-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
White adipose inflammation can occur in obesity and is at least in part mediated by inflammatory immune cells. Here the authors show that the Type I Interferon/Interferon alpha-beta receptor axis promotes an inflammatory, glycolysis associated adipocyte phenotype.
