PLoS ONE (Jan 2020)

Intraocular pressure reduction in a pigmentary glaucoma model by Goniotome Ab interno trabeculectomy.

  • Chao Wang,
  • Yalong Dang,
  • Priyal Shah,
  • Hamed Esfandiari,
  • Ying Hong,
  • Ralitsa T Loewen,
  • Susannah Waxman,
  • Sarah Atta,
  • Xiaobo Xia,
  • Nils A Loewen

DOI
https://doi.org/10.1371/journal.pone.0231360
Journal volume & issue
Vol. 15, no. 4
p. e0231360

Abstract

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PurposeTo investigate whether microsurgical excision of trabecular meshwork (TM) in an ex vivo pigmentary glaucoma model can normalize the hypertensive phenotype.MethodsEight eyes of a porcine pigmentary glaucoma model underwent 90° of microsurgical TM excision with an aspirating dual-blade (Goniotome (G)). 24 hours later, additional 90° of TM were removed. Anterior segments with sham surgeries served as the control (C). Outflow facility and intraocular pressure (IOP) were analyzed. Histology with hematoxylin and eosin (H&E) was obtained.ResultsAfter the first 90° TM excision, IOP was significantly lower in G (10.2±2.4 mmHg, n = 7) than C (20.0±2.0mmHg, n = 8, PConclusionsExcision of 90° of TM in a pigmentary glaucoma model using an aspirating dual-blade decreased IOP and increased outflow facility.