Nature Communications (Jul 2017)

Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin

  • Weiyi Wang,
  • Soraya Cantos-Fernandes,
  • Yuncong Lv,
  • Hureshitanmu Kuerban,
  • Shoeb Ahmad,
  • Chunguang Wang,
  • Benoît Gigant

DOI
https://doi.org/10.1038/s41467-017-00091-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that kinesin-13 functions by stabilizing a curved tubulin conformation.