1,2,3-Triazoles: Controlled Switches in Logic Gate Applications
Debanjana Ghosh,
Austin Atkinson,
Jaclyn Gibson,
Harini Subbaiahgari,
Weihua Ming,
Clifford Padgett,
Karelle S. Aiken,
Shainaz M. Landge
Affiliations
Debanjana Ghosh
Department of Chemistry and Biochemistry, Georgia Southern University (Statesboro Campus), 521 College of Education Drive, Statesboro, GA 30460-8064, USA
Austin Atkinson
Department of Chemistry and Biochemistry, Georgia Southern University (Statesboro Campus), 521 College of Education Drive, Statesboro, GA 30460-8064, USA
Jaclyn Gibson
Department of Chemistry and Biochemistry, Georgia Southern University (Statesboro Campus), 521 College of Education Drive, Statesboro, GA 30460-8064, USA
Harini Subbaiahgari
Department of Chemistry, Science Building West, Southern Illinois University Edwardsville, Edwardsville, IL 62026-1652, USA
Weihua Ming
Department of Chemistry and Biochemistry, Georgia Southern University (Statesboro Campus), 521 College of Education Drive, Statesboro, GA 30460-8064, USA
Clifford Padgett
Department of Chemistry and Biochemistry, Georgia Southern University (Armstrong Campus), 11935 Abercorn Street, Savannah, GA 31419, USA
Karelle S. Aiken
Department of Chemistry and Biochemistry, Georgia Southern University (Statesboro Campus), 521 College of Education Drive, Statesboro, GA 30460-8064, USA
Shainaz M. Landge
Department of Chemistry and Biochemistry, Georgia Southern University (Statesboro Campus), 521 College of Education Drive, Statesboro, GA 30460-8064, USA
A 1,2,3-triazole-based chemosensor is used for selective switching in logic gate operations through colorimetric and fluorometric response mechanisms. The molecular probe synthesized via “click chemistry” resulted in a non-fluorescent 1,4-diaryl-1,2,3-triazole with a phenol moiety (PTP). However, upon sensing fluoride, it TURNS ON the molecule’s fluorescence. The TURN-OFF order occurs through fluorescence quenching of the sensor when metal ions, e.g., Cu2+, and Zn2+, are added to the PTP-fluoride ensemble. A detailed characterization using Nuclear Magnetic Resonance (NMR) spectroscopy in a sequential titration study substantiated the photophysical characteristics of PTP through UV-Vis absorption and fluorescence profiles. A combination of fluorescence OFF-ON-OFF sequences provides evidence of 1,2,3-triazoles being controlled switches applicable to multimodal logic operations. The “INH” gate was constructed based on the fluorescence output of PTP when the inputs are F− and Zn2+. The “IMP” and “OR” gates were created on the colorimetric output responses using the probe’s absorption with multiple inputs (F− and Zn2+ or Cu2+). The PTP sensor is the best example of the “Write-Read-Erase-Read” mimic.
