Nature Communications (Dec 2021)
Impact of maternal antibodies and microbiota development on the immunogenicity of oral rotavirus vaccine in African, Indian, and European infants
- Edward P. K. Parker,
- Christina Bronowski,
- Kulandaipalayam Natarajan C. Sindhu,
- Sudhir Babji,
- Blossom Benny,
- Noelia Carmona-Vicente,
- Nedson Chasweka,
- End Chinyama,
- Nigel A. Cunliffe,
- Queen Dube,
- Sidhartha Giri,
- Nicholas C. Grassly,
- Annai Gunasekaran,
- Deborah Howarth,
- Sushil Immanuel,
- Khuzwayo C. Jere,
- Beate Kampmann,
- Jenna Lowe,
- Jonathan Mandolo,
- Ira Praharaj,
- Bakthavatsalam Sandya Rani,
- Sophia Silas,
- Vivek Kumar Srinivasan,
- Mark Turner,
- Srinivasan Venugopal,
- Valsan Philip Verghese,
- Alistair C. Darby,
- Gagandeep Kang,
- Miren Iturriza-Gómara
Affiliations
- Edward P. K. Parker
- The Vaccine Centre, Department of Clinical Research, London School of Hygiene and Tropical Medicine
- Christina Bronowski
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Kulandaipalayam Natarajan C. Sindhu
- Division of Gastrointestinal Sciences, Christian Medical College
- Sudhir Babji
- Division of Gastrointestinal Sciences, Christian Medical College
- Blossom Benny
- Division of Gastrointestinal Sciences, Christian Medical College
- Noelia Carmona-Vicente
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Nedson Chasweka
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi
- End Chinyama
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi
- Nigel A. Cunliffe
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Queen Dube
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi
- Sidhartha Giri
- Division of Gastrointestinal Sciences, Christian Medical College
- Nicholas C. Grassly
- Department of Infectious Disease Epidemiology, Imperial College London
- Annai Gunasekaran
- Division of Gastrointestinal Sciences, Christian Medical College
- Deborah Howarth
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Sushil Immanuel
- Division of Gastrointestinal Sciences, Christian Medical College
- Khuzwayo C. Jere
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Beate Kampmann
- The Vaccine Centre, Department of Clinical Research, London School of Hygiene and Tropical Medicine
- Jenna Lowe
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Jonathan Mandolo
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi
- Ira Praharaj
- Division of Gastrointestinal Sciences, Christian Medical College
- Bakthavatsalam Sandya Rani
- Division of Gastrointestinal Sciences, Christian Medical College
- Sophia Silas
- Division of Gastrointestinal Sciences, Christian Medical College
- Vivek Kumar Srinivasan
- Division of Gastrointestinal Sciences, Christian Medical College
- Mark Turner
- Institute of Life Course and Medical Sciences, University of Liverpool
- Srinivasan Venugopal
- Division of Gastrointestinal Sciences, Christian Medical College
- Valsan Philip Verghese
- Department of Child Health, Christian Medical College
- Alistair C. Darby
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- Gagandeep Kang
- Division of Gastrointestinal Sciences, Christian Medical College
- Miren Iturriza-Gómara
- Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
- DOI
- https://doi.org/10.1038/s41467-021-27074-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Oral rotavirus vaccine (ORV) efficacy varies between countries, but underlying reasons aren’t fully understood. In this prospective cohort study, authors show that maternal rotavirus-specific antibodies in serum and breastmilk and pre-vaccination microbiota diversity are negatively correlated with ORV response in India and Malawi but not in the UK.
