Nature Communications (Mar 2022)

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation

  • Marta Kapalczynska,
  • Manqiang Lin,
  • Jeroen Maertzdorf,
  • Julian Heuberger,
  • Stefanie Muellerke,
  • Xiangsheng Zuo,
  • Ramon Vidal,
  • Imad Shureiqi,
  • Anne-Sophie Fischer,
  • Sascha Sauer,
  • Hilmar Berger,
  • Evelyn Kidess,
  • Hans-Joachim Mollenkopf,
  • Frank Tacke,
  • Thomas F. Meyer,
  • Michael Sigal

DOI
https://doi.org/10.1038/s41467-022-29176-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Helicobacter pylori causes gastric inflammation, gland hyperplasia and is linked to gastric cancer. Here the authors identify a BMP feedback loop between the stomach epithelium and surrounding stroma that controls gland homeostasis and demonstrate its interruption upon infection with H. pylori.