Nature Communications (Aug 2021)

The structure of the bacterial DNA segregation ATPase filament reveals the conformational plasticity of ParA upon DNA binding

  • Alexandra V. Parker,
  • Daniel Mann,
  • Svetomir B. Tzokov,
  • Ling C. Hwang,
  • Julien R. C. Bergeron

DOI
https://doi.org/10.1038/s41467-021-25429-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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ParA is an ATPase involved in the segregation of newly replicated DNA in bacteria. Here, structures of a ParA filament bound to DNA and of ParA in various nucleotide states offer insight into its conformational changes upon DNA binding and filament assembly, including the basis for ParA’s cooperative binding to DNA.