Magnetic Composite Submicron Carriers with Structure-Dependent MRI Contrast
Anastasiia A. Kozlova,
Sergey V. German,
Vsevolod S. Atkin,
Victor V. Zyev,
Maxwell A. Astle,
Daniil N. Bratashov,
Yulia I. Svenskaya,
Dmitry A. Gorin
Affiliations
Anastasiia A. Kozlova
Biomedical photoacoustics lab, Saratov State University, Saratov 410012, Russia
Sergey V. German
Laboratory of objects and spectroscopy of nanoobjects of molecular spectroscopy department, Institute of Spectroscopy of the Russian Academy of Sciences (ISAN), Troitsk 108840, Russia
Vsevolod S. Atkin
Research and Educational Institute of Nanostructures and Biosystems, Saratov State University, Saratov 410012, Russia
Victor V. Zyev
Scientific Research Institute of Fundamental and Clinical Uronephrology, Saratov State Medical University, Saratov 410012, Russia
Maxwell A. Astle
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK
Daniil N. Bratashov
Biomedical photoacoustics lab, Saratov State University, Saratov 410012, Russia
Yulia I. Svenskaya
Research and Educational Institute of Nanostructures and Biosystems, Saratov State University, Saratov 410012, Russia
Dmitry A. Gorin
Skolkovo Institute of Science and Technology, Skolkovo Innovation Center, Moscow 121205, Russia
Magnetic contrast agents are widely used in magnetic resonance imaging in order to significantly change the signals from the regions of interest in comparison with the surrounding tissue. Despite a high variety of single-mode T1 or T2 contrast agents, there is a need for dual-mode contrast from the one agent. Here, we report on the synthesis of magnetic submicron carriers, containing Fe3O4 nanoparticles in their structure. We show the ability to control magnetic resonance contrast by changing not only the number of magnetite nanoparticles in one carrier or the concentration of magnetite in the suspension but also the structure of the core−shell itself. The obtained data open up the prospects for dual-mode T1/T2 magnetic contrast formation, as well as provides the basis for future investigations in this direction.
