Nature Communications (Feb 2020)

Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

  • Guolin Ma,
  • Lian He,
  • Shuzhong Liu,
  • Jiansheng Xie,
  • Zixian Huang,
  • Ji Jing,
  • Yi-Tsang Lee,
  • Rui Wang,
  • Hesheng Luo,
  • Weidong Han,
  • Yun Huang,
  • Yubin Zhou

DOI
https://doi.org/10.1038/s41467-020-14841-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

Read online

Optogenetic tools have been used to control cellular behaviours but their use to probe structure-function relations of signalling proteins are underexplored. Here the authors engineer optogenetic modules into STIM1 to dissect molecular details of STIM1-mediated signalling and control various cellular events.