IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway

Qi Li; Yue Li; Fengjiao Wu; Jingyu Li; Zhongsha Li; Xiaoling Qin; Simeng Wei; Chang Chen

doi:10.1080/19336918.2023.2265158

Cell Adhesion & Migration (Dec 2023)

IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via modulating the JAK-1/STAT-3 signaling pathway

Qi Li,
Yue Li,
Fengjiao Wu,
Jingyu Li,
Zhongsha Li,
Xiaoling Qin,
Simeng Wei,
Chang Chen

Affiliations

Qi Li: The Biotherapy Center, Tumor Hospital of Harbin Medical University, Harbin, P. R. China
Yue Li: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China
Fengjiao Wu: The Biotherapy Center, Tumor Hospital of Harbin Medical University, Harbin, P. R. China
Jingyu Li: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China
Zhongsha Li: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China
Xiaoling Qin: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China
Simeng Wei: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China
Chang Chen: Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, P. R. China

DOI: https://doi.org/10.1080/19336918.2023.2265158
Journal volume & issue: Vol. 17, no. 1
pp. 1 – 10

Abstract

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ABSTRACTThe aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the JAK-1/STAT-3/NOX-4 signaling pathway. Antagonizing the high intracellular ROS that was induced by rhIL-13 promoted the migration of HUVECs. Furthermore, IL-13 neutralization not only inhibited intimal hyperplasia, but also promoted the migration of endothelial cells (ECs) after injury. The results suggest that IL-13 inhibition is a potential means of stimulating endothelial cells recovery after injury. Therefore, the attenuation of IL-13 activation may have therapeutic value for vascular disease.

Published in Cell Adhesion & Migration

ISSN: 1933-6918 (Print); 1933-6926 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Cytology
Website: https://www.tandfonline.com/journals/kcam

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