Correlation of C-reactive protein with clinical outcome in critically ill patients with sepsis

Abstract

Introduction: Biomarkers like C-reactive protein (CRP) identify patients with sepsis and are helpful in predicting the severity of sepsis. The objective of the study was to correlate CRP with mortality in patients with sepsis admitted to intensive care unit. Methods: The study was a prospective, observational study conducted in intensive care unit (ICU) of a tertiary teaching hospital over a period of two years. Critically ill patients with sepsis were included in the study. After ICU admission, patients were stabilized and samples for CRP, procalcitonin, serum lactate were analysed on the day of admission, day 2 and day 5. Results: Out of 90 critically ill patients, 45 patients were survivors and 45 patients were non-survivors. The mean percentage drop in CRP in survivors was 14.7 % on day 2 (p < 0.001 on day 2) and 57.5 % on day 5 (p < 0.001 on day 5) and mean percentage rise in CRP in non survivors was 15.1% on day 2 (p < 0.001 on day 2) and 25.5% on day 5 (p < 0.001 on day 5). The mean percentage drop in SOFA score in survivors was 30% on day 2 (p < 0.001) and 74% on day 5 (p < 0.001). Conclusion: Percentage change in CRP correlates with mortality, SOFA score, serum lactate values and duration of ICU stay in critically ill patients admitted with sepsis.

Keywords

• c–reactive protein
• ill patients
• sepsis
• sofa score