The absorptive and metabolic features of phagocytosis in children, depending on the frequency of acute respiratory infections

Abstract

Purpose of the study. To improve of innate immune disorders diagnosis in preschool children with respiratory tract recurrent infectious diseases on the basis of new data of phagocytosis parameters by studying its absorption and prooxidant characteristics. Materials and methods. Under observation were 60 children aged 2 to 5 years. Two groups were formed: 1). children with respiratory tract acute infectious more than 6 times in year (n = 30); 2). children with respiratory tract acute infectious 6 or less times in year (n = 30). Results. Among children in 1 group, statistically significantly increased the registration quantity of low phagocytic counts (by 60,0%, p < 0,05), phagocytic index (by 56,0%, p < 0,05), index of phagocytosis completeness (70,0%, p < 0,05), neutrophil phagocytic activity stimulated by staphylococcus (50,0%, p < 0,05) and high rates of spontaneous neutrophil phagocytic activity (43,3%, p < 0,05), high serum levels of lipid hydroperoxides (by 80,0%, p < 0,05), diene conjugates (by 80,0%, p < 0,05), malonic dialdehyde (76,7%, p < 0.05), diene ketones (76,7%, p < 0,05), Schiff bases (76,7%, p < 0,05). Conclusion. In children 2–5 years with respiratory tract acute infectious more than 6 times in year the phagocytic dysfunction and increased lipid peroxidation were established. It is characterizing the failure and slowness of the early immune response.

Keywords

• children
• respiratory infections
• immunity
• phagocytosis
• peroxidation