Nature Communications (May 2019)
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
Abstract
Rotaviruses are of great medical significance because they cause gastroenteritis in children. Here the authors provide insights into the mechanism of viral mRNA transcription by determining the in situ cryo-EM structures of a working rotavirus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design.