Nature Communications (Jun 2018)
Pervasive genetic interactions modulate neurodevelopmental defects of the autism-associated 16p11.2 deletion in Drosophila melanogaster
- Janani Iyer,
- Mayanglambam Dhruba Singh,
- Matthew Jensen,
- Payal Patel,
- Lucilla Pizzo,
- Emily Huber,
- Haley Koerselman,
- Alexis T. Weiner,
- Paola Lepanto,
- Komal Vadodaria,
- Alexis Kubina,
- Qingyu Wang,
- Abigail Talbert,
- Sneha Yennawar,
- Jose Badano,
- J. Robert Manak,
- Melissa M. Rolls,
- Arjun Krishnan,
- Santhosh Girirajan
Affiliations
- Janani Iyer
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Mayanglambam Dhruba Singh
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Matthew Jensen
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Payal Patel
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Lucilla Pizzo
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Emily Huber
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Haley Koerselman
- Department of Biology, University of Iowa
- Alexis T. Weiner
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Paola Lepanto
- Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo
- Komal Vadodaria
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Alexis Kubina
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Qingyu Wang
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Abigail Talbert
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Sneha Yennawar
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Jose Badano
- Human Molecular Genetics Laboratory, Institut Pasteur de Montevideo
- J. Robert Manak
- Department of Biology, University of Iowa
- Melissa M. Rolls
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- Arjun Krishnan
- Department of Computational Mathematics, Science and Engineering, Michigan State University
- Santhosh Girirajan
- Department of Biochemistry and Molecular Biology, The Pennsylvania State University
- DOI
- https://doi.org/10.1038/s41467-018-04882-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 19
Abstract
The 16p11.2 deletion leads to a range of neurodevelopmental phenotypes, but to date, sequencing studies have not been able to pinpoint individual genes that are causative for the disease on their own. Here, using Drosophila homologs of 14 16p11.2 genes, the authors take a combinatorial approach to show that gene interactions contribute to a neurological phenotype.
