Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

Hamid R. Noori; Lewis H. Mervin; Vahid Bokharaie; Özlem Durmus; Lisamon Egenrieder; Stefan Fritze; Britta Gruhlke; Giulia Reinhardt; Hans-Hendrik Schabel; Sabine Staudenmaier; Nikos K. Logothetis; Andreas Bender; Rainer Spanagel

doi:10.1038/s41467-018-07239-1

Nature Communications (Nov 2018)

Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

Hamid R. Noori,
Lewis H. Mervin,
Vahid Bokharaie,
Özlem Durmus,
Lisamon Egenrieder,
Stefan Fritze,
Britta Gruhlke,
Giulia Reinhardt,
Hans-Hendrik Schabel,
Sabine Staudenmaier,
Nikos K. Logothetis,
Andreas Bender,
Rainer Spanagel

Affiliations

Hamid R. Noori: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Lewis H. Mervin: Centre for Molecular Informatics, Department of Chemistry, University of Cambridge
Vahid Bokharaie: Max Planck Institute for Biological Cybernetics, Max Planck Ring 8
Özlem Durmus: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Lisamon Egenrieder: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Stefan Fritze: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Britta Gruhlke: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Giulia Reinhardt: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Hans-Hendrik Schabel: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Sabine Staudenmaier: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg
Nikos K. Logothetis: Max Planck Institute for Biological Cybernetics, Max Planck Ring 8
Andreas Bender: Centre for Molecular Informatics, Department of Chemistry, University of Cambridge
Rainer Spanagel: Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg

DOI: https://doi.org/10.1038/s41467-018-07239-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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The precise relationship between neurobehavioural effects and neurotransmitter effects of psychiatric drugs are not always understood. Here the authors develop a database documenting the neurotransmitter response in rats to 258 different neuropsychiatric drugs, and conclude that this neurotransmitter response does not, in general, reflect the current categorisation of those drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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