Necrolytic migratory ulceration

Abstract

Endocrine tumors of the gastroenteropancreatic system associated with specific skin manifestations are rare. We report a 53-year-old female who presented with migratory annular and arcuate ulcers on her limbs. Histopathology was similar to necrolytic erythema family which includes necrolytic migratory erythema (NME). Though initial CT scans were normal, follow up scans revealed multiple mass lesions in the tail of pancreas. Her skin lesions responded to oral zinc sulphate and monthly injections of octreotide. Prior to planned FNAC from the mass lesion, patient developed altered sensorium and succumbed to the disease. This case report seems to differ from NME clinically, due to unique finding of deep migrating ulcers which heal with scarring. ′Necrolytic migratory ulceration′ thus appears to be a new paraneoplastic manifestation, secondary to pancreatic malignancy.

Keywords

• Migratory ulcers
• necrolytic erythema
• necrolytic migratory erythema
• pancreatic tumor