Nature Communications (Feb 2023)
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients
- Romain Rouet,
- Jake Y. Henry,
- Matt D. Johansen,
- Meghna Sobti,
- Harikrishnan Balachandran,
- David B. Langley,
- Gregory J. Walker,
- Helen Lenthall,
- Jennifer Jackson,
- Stephanie Ubiparipovic,
- Ohan Mazigi,
- Peter Schofield,
- Deborah L. Burnett,
- Simon H. J. Brown,
- Marianne Martinello,
- Bernard Hudson,
- Nicole Gilroy,
- Jeffrey J. Post,
- Anthony Kelleher,
- Hans-Martin Jäck,
- Christopher C. Goodnow,
- Stuart G. Turville,
- William D. Rawlinson,
- Rowena A. Bull,
- Alastair G. Stewart,
- Philip M. Hansbro,
- Daniel Christ
Affiliations
- Romain Rouet
- Garvan Institute of Medical Research
- Jake Y. Henry
- Garvan Institute of Medical Research
- Matt D. Johansen
- Center for Inflammation, Centenary Institute and University of Technology Sydney
- Meghna Sobti
- UNSW Sydney, St Vincent’s Clinical School, Faculty of Medicine
- Harikrishnan Balachandran
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- David B. Langley
- Garvan Institute of Medical Research
- Gregory J. Walker
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- Helen Lenthall
- Garvan Institute of Medical Research
- Jennifer Jackson
- Garvan Institute of Medical Research
- Stephanie Ubiparipovic
- Garvan Institute of Medical Research
- Ohan Mazigi
- Garvan Institute of Medical Research
- Peter Schofield
- Garvan Institute of Medical Research
- Deborah L. Burnett
- Garvan Institute of Medical Research
- Simon H. J. Brown
- Molecular Horizons, University of Wollongong
- Marianne Martinello
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- Bernard Hudson
- Royal North Shore Hospital
- Nicole Gilroy
- Westmead Hospital
- Jeffrey J. Post
- Prince of Wales Hospital
- Anthony Kelleher
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- Hans-Martin Jäck
- Division of Molecular Immunology, Friedrich-Alexander University Erlangen-Nürnberg and University Hospital Erlangen
- Christopher C. Goodnow
- Garvan Institute of Medical Research
- Stuart G. Turville
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- William D. Rawlinson
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- Rowena A. Bull
- UNSW Sydney, School of Medical Sciences, Faculty of Medicine
- Alastair G. Stewart
- UNSW Sydney, St Vincent’s Clinical School, Faculty of Medicine
- Philip M. Hansbro
- Prince of Wales Hospital
- Daniel Christ
- Garvan Institute of Medical Research
- DOI
- https://doi.org/10.1038/s41467-023-36295-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Here, Rouet et al. present a strategy for the identification of broadly neutralising antibodies against SARS-CoV-2 receptor binding domain from peripheral blood mononuclear cells of convalescent patients, which enabled the identification of a new class 6 epitope.
