mBio (Jun 2021)

Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

  • Yue Zheng,
  • Heidi L. Schubert,
  • Parmit K. Singh,
  • Laura J. Martins,
  • Alan N. Engelman,
  • Iván D’Orso,
  • Christopher P. Hill,
  • Vicente Planelles

DOI
https://doi.org/10.1128/mBio.01098-21
Journal volume & issue
Vol. 12, no. 3

Abstract

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CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin. Our observations reveal a second role of CPSF6 in the HIV-1 life cycle that involves regulation of viral transcription through controlling the stability of protein phosphatase 2A, which in turn regulates the phosphorylation/dephosphorylation status of critical residues in CDK9 and Pol II.