Sonodynamic therapy with photosensitizers and its combination with photodynamic therapy in treatment of malignant tumors

Abstract

The article reviews mechanisms of sonodynamic therapy with photosensitizers (ultrasound + photosensitizer) and combination of sonodynamic with photodynamic therapy (ultrasound + photosensitizer + light exposure) for treatment of malignant tumors. Efficacy of these methods with photosensitizers of different chemical structure in experimental study in vitro and in vivo on different tumor models and in clinical trials was assessed.

Keywords

• ультразвук
• сонодинамическая терапия
• комбинированное лечение
• соносенсибилизаторы
• фотосенсибилизаторы