CANDIDATE LABORATORY MARKERS OF LONG-TERM FUNCTIONING OF THE DUCTUS ARTERIOSUS IN EXTREMELY LOW BIRTH WEIGHT INFANTS

Abstract

Objective. Pathogenetic relationships between clinical, biochemical blood parameters and long-term functioning of the patent ductus arteriosus (PDA) in newborns with extremely low birth weight (ELBW). Purpose of the study – to identify candidate markers of a functioning hemodynamically significant patent ductus arteriosus in newborns with ELBW from among routinely measured clinical and biochemical blood parameters. Methods. Observational, retrospective, case / control study; the grouping factor was a long-term hemodynamically significant patent ductus arteriosus. The following indicators were analyzed: hemoglobin, leukocyte intoxication index, platelets, potassium, sodium, calcium, glucose – comparison of the studied indicators between the two groups, as well as within each group was carried out in three periods of life: 1-2 weeks, 3-4 week and 2nd month of life. Results. Statistically significant differences between the compared groups of newborns were found in the period 1-2 weeks of life in terms of hemoglobin, platelets and potassium levels, which is pathogenetically substantiated. The dynamics of potassium, sodium and leukocyte intoxication index levels obtained by us within the studied groups also indirectly indicates the role of hypoxia and inflammation in the process of PDA closure in newborns with ELBW. Conclusions. The found additional markers can be used to predict long-term functioning PDA and select the optimal management tactics for newborns with ELBW. There is a pathogenetic relationship between the level of hemoglobin, platelets, potassium with long-term persistent PDA.

Keywords

• недоношенные новорожденные
• длительно функционирующий артериальный проток
• лабораторные маркеры