npj Digital Medicine (May 2025)

A multivariate model incorporating subharmonic measurements for evaluating vocal roughness

  • Itsuki Kitayama,
  • Kiyohito Hosokawa,
  • Shinobu Iwaki,
  • Misao Yoshida,
  • Akira Miyauchi,
  • Kenji Aruga,
  • Takanari Kawabe,
  • Toshihiro Kishikawa,
  • Hidenori Tanaka,
  • Takeshi Tsuda,
  • Takashi Sato,
  • Yukinori Takenaka,
  • Makoto Ogawa,
  • Hidenori Inohara

DOI
https://doi.org/10.1038/s41746-025-01702-2
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Abstract The assessment of voice quality plays a critical role in the clinical evaluation of hoarseness. However, no study has established a highly accurate method for the auditory–perceptual judgment of vocal roughness, which is one of the major components of hoarseness. In this study, we developed a multivariate acoustic model for quantifying vocal roughness using a tailored fundamental frequency (f o ) estimation algorithm. The newly devised parameters enabled the classification and quantification of subharmonics, a key component of rough voice. Furthermore, we introduce the acoustic roughness index (ARI), a predictive acoustic model that integrates these parameters with existing acoustic parameters. The ARI demonstrates high diagnostic accuracy and a strong correlation with auditory–perceptual roughness, establishing it as a robust index for the evaluation of vocal roughness.