Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

Daniel F. Cardozo Pinto; Hongbin Yang; Iskra Pollak Dorocic; Johannes W. de Jong; Vivian J. Han; James R. Peck; Yichen Zhu; Christine Liu; Kevin T. Beier; Marten P. Smidt; Stephan Lammel

doi:10.1038/s41467-019-12392-2

Nature Communications (Oct 2019)

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe

Daniel F. Cardozo Pinto,
Hongbin Yang,
Iskra Pollak Dorocic,
Johannes W. de Jong,
Vivian J. Han,
James R. Peck,
Yichen Zhu,
Christine Liu,
Kevin T. Beier,
Marten P. Smidt,
Stephan Lammel

Affiliations

Daniel F. Cardozo Pinto: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Hongbin Yang: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Iskra Pollak Dorocic: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Johannes W. de Jong: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Vivian J. Han: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
James R. Peck: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Yichen Zhu: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Christine Liu: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley
Kevin T. Beier: Departments of Physiology and Biophysics, Center for the Neurobiology of Learning and Memory, University of California Irvine
Marten P. Smidt: Swammerdam Institute for Life Sciences, FNWI University of Amsterdam
Stephan Lammel: Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California Berkeley

DOI: https://doi.org/10.1038/s41467-019-12392-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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In addition to serotonin neurons, the dorsal raphe nucleus (DR) also contains dopamine, glutamate, and GABA neurons. Here, the authors systematically compare the neurochemical identity, cell type specificity, anatomical distribution, and connectivity of DR cells targeted by commonly used Cre lines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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