Jichu yixue yu linchuang (Mar 2024)

Research progress on P2X7 receptor in cancer pain

  • ZHANG Zhongwen, ZHAO Rui, ZHANG Haolong, YANG Yuting, BAI Jinxia, ZHANG Haoling WANG Wei

DOI
https://doi.org/10.16352/j.issn.1001-6325.2024.03.0389
Journal volume & issue
Vol. 44, no. 3
pp. 389 – 392

Abstract

Read online

The activation of the P2X7 receptor as an ATP-gated ion channel, triggers the release of pro-inflammatory cytokines in tumor carring individuals and stimulate excitation of injury-causing neurons, thereby exacerbating the transmission of pain. In preclinical cancer pain models, it has the potential to serve as a new therapeutic target for cancer pain management.

Keywords