Association between vitamin A, E, and folate levels and risk of non-alcoholic fatty liver disease in adults with diabetes mellitus

Abstract

Abstract Antioxidant vitamin deficiency may contribute to the development of metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD). This study aimed to analyze the association between serum vitamin A, E, and folate levels and NAFLD in adults with diabetes mellitus. Using data from the Korean National Health and Nutrition Examination Survey (2016–2018), we conducted a cross-sectional analysis of adults over 19 with diabetes. NAFLD was identified through three prediction tools. Of 589 participants, 326, 445, and 527 had NAFLD according to the hepatic steatosis index, Framingham steatosis index (FSI), and comprehensive NAFLD score (CNS), respectively. Serum vitamin E levels were consistently higher in the NAFLD group across all diagnostic tools. Similarly, vitamin A levels were elevated in those with NAFLD as per the CNS. Folate levels were higher in the obese group according to the FSI. After adjusting for covariates, both vitamin A and E levels were positively associated with NAFLD. This suggests that higher serum levels of vitamins A and E may increase the risk of NAFLD in the Korean diabetic population. These findings highlight the importance of monitoring micronutrient levels in managing NAFLD in patients with diabetes.

Keywords

• Diabetes mellitus
• NAFLD
• Vitamin A
• Vitamin E
• Folate