Dissolution of Curcumin Microencapsulation Coated by Chitosan-Alginate-Glutaraldehide

Abstract

In vitro dissolution of curcumin coated by chitosan-alginate gel in its optimum condition was studied. The maceration process using 17.08% ethanol yields and the content of the curcumin in the extract detected by visible spectrophotometry  430 nm is found to be 10.30%. its optimum condition was obtained using response surface method at concentration was fixed (1.75% [b/v]). The dissolution assay was done at 37 C, at 100 rpm of stirring rate in 8 hours. Aliquots were taken at 15, 30, 45, 60, 90, 120, 150, 180, 240, 300, 360, 420, 480 minutes. Absorbance of the Aliquots was measured at  430 nm. The curcumin released has the best linear correlation to the first order reaction with releasesd constant, k = 2.24 10-3 minute-1 while it’s half live is t1/2 = 5.16 hours. Release curcumin was determined mainly by diffusion mechanism. Compared to the result based on Fick model, the one of Higuchi model is better in agreement in reproducing the released data.

Keywords

• chitosan-alginate-glutaraldehide
• curcumin
• diffusion-dissolution
• microencapsulation