Markers of fibrosis in ischemic chronic heart failure and renal dysfunction

Abstract

Aim. Features of the extracellular matrix metabolism depending on the state of renal function were identified in 113 patients with ischemic chronic heart failure using ELISA, echocardiography. Methods and results. Activity of collagen metabolism markers (MMP-9, TIMP-1, РІСР), cystatin C, structural and functional parameters of the heart were studied. It was established that the presence of moderate renal dysfunction in ischemic chronic heart failure was associated with age, history of myocardial infarction and hypertension, accompanied by the increasing of NT-proBNP, cystatin C, MMP-9 and was characterized by structural remodeling of the left atrium and ventricle with increased systolic pressure in the pulmonary artery, the deterioration of systolic and diastolic function.

Keywords

• Heart Failure
• Biomarkers
• Fibrosis
• Kidney