Antimicrobial and pesticidal activity of some organogermanium(IV) complexes synthesized under microwave irradiation

Abstract

Reactions of 2-hydroxy-N-phenylbenzamide with semicarbazide hydrochloride and thiosemicarbazide resulted in the formation of new ketimines, semicarbazone and thiosemicarbazone of 2-hydroxy-N-phenylbenzamide, respectively. The organogermanium(IV) complexes have been synthesized by reacting trimethylgermanium chloride and triphenylgermanium chloride in a 1:1 molar ratio with these ketimines using microwave as well as conventional heating method for comparison purposes. The authenticity of these ligands and their complexes has been established on the basis of elemental analysis, melting point determinations, molecular weight determinations, infrared, 1H and 13C nuclear magnetic resonance, ultraviolet, and mass spectral studies. These studies showed that the ketimines coordinated with the germanium atom and, accordingly, the trigonal bipyramidal environment around the metal atom has been established for the complexes. Both the ketimines and their complexes have been screened for their antimicrobial activities against a variety of fungal and bacterial strains and were found positive in this respect. The pesticidal activity of both the ligands and their metal complexes against the Corcyra cephalonica has also been tested.

Keywords

• antimicrobial
• ketimines
• pesticidal activity
• semicarbazone
• spectral studies
• thiosemicarbazone