Evaluation of the influence of thiotriazoline on the cytokine status disturbances in the blood serum under the condition of experimental contact dermatitis and experimental pneumonia

Abstract

The aim of our research was to determine the character of the disturbances content level of pro-inflammatory interleukin-6, tumor necrosis factor-α and anti-inflammatory cytokine interleukin-10 (IL-10) in the serum of guinea pigs and estimation of thiotriazoline influence on the cytokine profile in the conditions of formation of combined pathology - experimental contact dermatitis and experimental pneumonia.It has been determined significant advantage of pro-inflammatory cytokine activity, which increasing according the development of the combined pathological process and, simultaneously, reducing the anti-inflammatory IL-10. It has been detected corrective action of thiotriazoline on the investigated indices of cytokine profile.

Keywords

• contact dermatitis
• pneumonia
• cytokines
• thiotriazoline