Lipopolysaccharide of the <i>Yersinia pseudotuberculosis</i> Complex
Yuriy A. Knirel,
Andrey P. Anisimov,
Angelina A. Kislichkina,
Anna N. Kondakova,
Olga V. Bystrova,
Anastasia S. Vagaiskaya,
Konstantin Y. Shatalin,
Alexander S. Shashkov,
Svetlana V. Dentovskaya
Affiliations
Yuriy A. Knirel
Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
Andrey P. Anisimov
Laboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia
Angelina A. Kislichkina
Laboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia
Anna N. Kondakova
Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
Olga V. Bystrova
Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
Anastasia S. Vagaiskaya
Laboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia
Konstantin Y. Shatalin
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
Alexander S. Shashkov
Laboratory of Carbohydrate Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
Svetlana V. Dentovskaya
Laboratory for Plague Microbiology, Especially Dangerous Infections Department, State Research Center for Applied Microbiology and Biotechnology, 142279 Obolensk, Russia
Lipopolysaccharide (LPS), localized in the outer leaflet of the outer membrane, serves as the major surface component of the Gram-negative bacterial cell envelope responsible for the activation of the host’s innate immune system. Variations of the LPS structure utilized by Gram-negative bacteria promote survival by providing resistance to components of the innate immune system and preventing recognition by TLR4. This review summarizes studies of the biosynthesis of Yersinia pseudotuberculosis complex LPSs, and the roles of their structural components in molecular mechanisms of yersiniae pathogenesis and immunogenesis.
