CHIMIA
(Apr 2013)
Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts
Françoise Borcard,
Phally Kong,
Céline Journot,
Davide Staedler,
Philip N. Sturzenegger,
Franziska Krauss Juillerat,
Urs T. Gonzenbach,
Lucienne Juillerat-Jeanneret,
Sandrine Gerber-Lemaire
Affiliations
Françoise Borcard
Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
Phally Kong
Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
Céline Journot
Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
Davide Staedler
Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
Philip N. Sturzenegger
Nonmetallic Inorganic Materials ETHZ, CH-8093 Zürich, Switzerland
Franziska Krauss Juillerat
Nonmetallic Inorganic Materials ETHZ, CH-8093 Zürich, Switzerland
Urs T. Gonzenbach
Nonmetallic Inorganic Materials ETHZ, CH-8093 Zürich, Switzerland
Lucienne Juillerat-Jeanneret
University Institute of Pathology CHUV-UNIL, CH-1011 Lausanne, Switzerland
Sandrine Gerber-Lemaire
Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland. [email protected]
DOI
https://doi.org/10.2533/chimia.2013.213
Journal volume & issue
Vol. 67,
no. 4
Abstract
Read online
Surface functionalization of hydroxyapatite (HA) and ?-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
Keywords
Published in CHIMIA
ISSN
0009-4293 (Print)
2673-2424 (Online)
Publisher
Swiss Chemical Society
Country of publisher
Switzerland
LCC subjects
Science: Chemistry
Website
http://chimia.ch
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